Statins for microvascular complications—all but the kidney
نویسندگان
چکیده
منابع مشابه
Statins and Kidney
Statins were derived from Penicillium citrinium in 1976 by Endo and his colleagues. Brown et al7 showed that they act by inhibiting HMG-CoA reductase. The first studied statin was compactin which was renamed mevastatin. Lovastatin became the first statin to be approved for human use. Pravastatin and simvastatin are chemically modified derivatives of lovastatin. Atorvastatin, fluvastatin and cer...
متن کاملStatins and the Kidney: Friend or Foe?
Statins essentially are cholesterol-lowering drugs that are extensively prescribed for primary and secondary prevention of cardiovascular disease. Compelling evidence suggests that the beneficial effects of statins may not only be due to controlling cholesterol levels but also due to a pleiotropic cholesterol-independent anti-inflammatory, antioxidant, endothelial-protective and plaque-stabiliz...
متن کاملStatins and the kidney: friend or foe?
Statins essentially are cholesterol-lowering drugs that are extensively prescribed for primary and secondary prevention of cardiovascular disease. Compelling evidence suggests that the beneficial effects of statins may not only be due to controlling cholesterol levels but also due to a pleiotropic cholesterol-independent anti-inflammatory, antioxidant, endothelial-protective and plaque-stabiliz...
متن کاملStatins in Chronic Kidney Disease- Are Statins Really Renoprotective
Numerous trials have shown that chronic kidney disease increases the risk of cardiovascular disease. Dyslipidemias have been shown to accelerate progression of kidney disease. Statins have assumed a pivotal role in management of hyperlipidemia. However their effect on renal function is still not fully understood. Some clinical trials have shown some renoprotective effect of statins but there is...
متن کاملStatins for the prevention of contrast-induced acute kidney injury.
PURPOSE OF REVIEW To highlight the most recently published meta-analyses on the role of statins in the prevention of contrast-induced acute kidney injury (CI-AKI) and to formulate recommendations for clinical practice. RECENT FINDINGS Nine meta-analyses were published on this topic from January 2015 to April 2016. Significant clinical heterogeneity between studies, regarding study population,...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2014
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2014.203